Modelling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion
نویسندگان
چکیده
1 Bioengineering Science Research Group, Faculty of Engineering and the Environment, and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, U.K. Division of Biomedical Engineering, Glasgow University, Glasgow G12 8QQ, UK Laboratoire de Modélisation Mathématiques et Simulation Numérique, Faculté des Sciences, Université Badji-Mokhtar, BP 12, 23000 Annaba, Algeria Department of Bioengineering, Imperial College London, London SW7 2AZ, UK Department of Mathematics, University of Surrey, Guildford GU2 7XH, UK Pharmaceutic Mineral Chemistry Laboratory, Université Badji-Mokhtar, BP 12, 23000 Annaba, Algeria Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Plc., King of Prussia, PA 19406, USA Respiratory DPU, GlaxoSmithKline Plc., Stevenage SG1 2NY, UK Drug Metabolism and Pharmacokinetics, GlaxoSmithKline Plc., Stevenage SG1 2NY, UK Corresponding author
منابع مشابه
Modeling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion
We have developed a mathematical framework for describing a bispecific monoclonal antibody interaction with two independent membrane-bound targets that are expressed on the same cell surface. The bispecific antibody in solution binds either of the two targets first, and then cross-links with the second one while on the cell surface, subject to rate-limiting lateral diffusion step within the lif...
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Blinatumomab, the bispecific T cell engager, has been demonstrated as the most successful BsAb to date. Throughout the past decade, vector design has great importance for the expression of monoclonal antibody in Chinese hamster ovary (CHO) cells. It has been indicated that expression plasmids based on the elongation factor-1 alpha (EF-1 alpha) gene and DHFR selection marker can be highly effect...
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